Effects of Testosterone Administration
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Although testosterone has a role in stimulating spermatogenesis, infertile men with a low sperm count do not benefit form testosterone treatment. Unless given at supraphysiological doses, exogenous testosterone cannot achieve the required local high concentration in the testis. One function o f androgen-binding protein in the testis is to sequester testosterone, which significantly increases its local concentration.
Exogenous testosterone given to men would normally inhibit endogenous LH release though a negative-feedback effect on the hypothalamic-pituitary axis, and lead to a suppression of testosterone production by the Leydig cells and a further decrease in testicular testosterone. Ultimately, because LH levels decrease when exogenous testosterone is administered, testicular size decreases, as has been reported for men who abuse androgens.
High levels of androgens have an anabolic effect on, muscle tissue, leading to increased muscle mass, strength, and performance, a desired result for body builders and athletes. Androgen abuse has been associated with abnormal aggressive behavior and the potential for increase incidence of liver and brain tumors
Filed Under: Family planning
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